Yi-Hui Zhou (周已会)

324 Ricks Hall

Campus Box 7566

North Carolina State University




PhD in Biostatistics, University of North Carolina, Chapel Hill


MS in Applied Mathematics, University of Maryland, Baltimore County

Research interests

High Dimensional Data Analysis
Statistical Genetics
Multiple testing

Academic Appointments

2018 - now

Associate Director of Outreach Bioinformatics Research Center

2014 - now

Research Assistant Professor North Carolina State University

2013 - 2014

Research Scholar North Carolina State University

2011 - 2013

Postdoc Research Associate University of North Carolina, Chapel Hill

Additional Appointments



Paul Gallins

Research Associate
301 Ricks Hall
Campus Box 7566

Tao Hu

Graduate Student
335 Ricks Hall
Campus Box 7566


Spring 2016 I am not teaching this semester.

Current Grants

Permutation Approximations for Next Generation Association

Funding Source: NIH (R21HG007840) 6/16/2015 ~ 4/30/2017
Role: Principal Investigator

Cardiotoxicity Adverse Outcome Pathway: Organotypic Culture Model and In Vitro/In Vivo Extrapolation for High-Throughput Hazard, Dose Response and Variability Assessments

Funding Source: EPA ( 83580201) 6/01/2015 ~ 5/31/2019
Role: Co-Investigator

The NCSU/RTI Program in Genetic Discovery and Prediction

Funding Source: RTI 12/01/2016 ~ 5/31/2019
Role: Co-Investigator

Multi-tissue and network models for next-generation eQTL studies

Funding Source: National Human Genome Research Institute (R01HG009125)
9/07/2016 ~ 6/30/2019
Role: Co-Investigator

Open Positions

A. Postdoctoral position in Statistical Genetics
B. Programmer

Key publications

For a complete list, please visit my Google Scholar page.

Zhou, Y.H., Cichocki, J.A., Soldatow, V.Y., Scholl, E.H., Gallins, P.J., Jima, D., Yoo, H., Chiu, W.A., Wright, F.A. Rusyn, I. (2017) “Editor’s Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.” Toxicological Sciences 160(1): 95-110

House, J.S., Grimm, F.A., Jima, D.D., Zhou, Y.H.,Rusyn, I., Wright, F.A. (2017) “A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics.” Frontiers in Genetics 8:168

Aoshima, M., Shen, D., Shen, H., Yata, K., Zhou, Y.H., Marron, J.S. (2018) “ A survey of high dimensional low sample size asymptotics.” Australian & New Zealand Journal of Statistics, 10.1111/anzs.12212

The GTEx Consortium (2017) “Dynamic landscape and regulation of RNA editing in mammals.” Nature, 550 (7675): 249

The GTEx Consortium (2017) “Co-expression networks reveal the tissue-specific regulation of transcription and splicing.” Genome Research 27:1843-1858

The GTEx Consortium (2017) “Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.” Genome Research 27:1859-1871

Palowitch, J., Shabalin, A., Zhou, Y.H., Nobel, A.B., Wright, F.A. (2017) “Estimation of cis‐eQTL effect sizes using a log of linear model." Biometrics DOI: 10.1111/biom.12810

Polineni, D., Dang, H., Gallins, P.J., Jones, L.C., Pace, R.G., Stonebraker, J.R., Commander, L.A., Krenicky, J.E., Zhou, Y.H., Corvol, H., Cutting, G.R., Drumm, M.L., Strug, J.L., Boyle, M.P., Durie, P.R., Chmiel, J.F., Zou, F., Wright, F.A., O'Neal, W.K., Knowles, M.R. (2017) “Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.” American Journal of Respiratory and Critical Care Medicine

Zhou, Y.H., Marron, J.S., Wright, F.A. (2017) “Eigenvalue significance testing for genetic association.” Biometrics DOI:10.1111/biom.12767

Zhou, Y.H., Marron, J.S., Wright, F.A. (2017) “Computation of ancestry scores with mixed families and unrelated individuals.” Biometrics DOI: 10.1111/biom.12708

Aguet, F., Brown, A.A., Castel,S., Davis, J.R., Mohammadi, P., Segre, A.V., Zappala, A., Abell, N.S., Fresard, L., Gamazon, E.R., Gelfand, E., Gloudemans, M.J., He, Y., Hormozdiari, F., Li, X., Li, X., Liu, B., Garrido-Martin, D., Ongen, H., Palowitch, J.J., Park, Y., Peterson, C.B., Quon, G., Ripke, S., Shabalin, A.A., Shimko, T.C., Strober, B.J., Sullivan, T.J., Teran, N.A., Tsang, E.K., Zhang, H., Zhou, Y.H.,, Battle, A., Bustamonte, C.D., Cox, N.J., Engelhardt, B.E., Eskin, E., Getz, G., Kellis, M., Li, G., MacArthur, D.G., Nobel, A.B., Sabbati, C., Wen, X.,, Wright, F.A., Lappalainen,T., Ardlie, K.G., Dermitzakis, E.T., Brown, C.D., Montgomery, S.D. (2017) “Local genetic effects on gene expression across 44 human tissues.” Nature volume 550, pages 204–213

Zhou, Y.H., Brooks, P., Wang, X. (2017) “A two-stage hidden Markov model design for biomarker detection, with application to microbiome research.” Statistics in BioSciences DOI:10.1007/s12561-017-9187y

Rudra, P., Zhou, Y.H., and Wright, F.A. (2017) “A procedure to detect general association based on concentration of ranks” Statistics 6 (1) 88-101

Brooks. J.P., Buck, G.A., Chen, G., Edwards, D.J., Fettweis, J.M., Rakitin, A., Satten, G.A., Waks, Z., Wright, M.L., Yanover, C., and Zhou, Y.H. (2017) “Changes in vaginal community state types reflect major shifts in the microbiome.” Microbial Ecology in Health and Disease, to appear.

Zhou, Y.H., Marron, J.S. (2016) “Visualization of robust L1PCA.” Stat DOI:10.1002/sta4.113

Luizon, M.R., Eckalbar, W.L., Wang, Y., Jones, S.L., Smith, R.P., Laurance, M., Lin, L., Gallins, P.J., Etheridge, A.S., Wright, F.A., Zhou, Y.H., Molony, C., Innocenti, F., Yee, S.W., Giacomini, K.M. and Ahituv, N. (2016) “Genomic Characterization of Metformin Hepatic Response.” PLoS Genetics, 12 (11), p.e1006449.

Tian, X., Pate, K., Ridpath, J.R., Zhou, Y.H., Neo, D., Clement, J., Takata, M., Takeda, S., Sale, J., Wright, F.A., Swenberg, J.A., Nakamura, J. (2016) “Homologous recombination and translesion DNA synthesis play critical roles on tolerating DNA damage caused by trace levels of hexavalent chromium” PLoS ONE 11(12):e0167403.

Zhou, Y.H. (2015) "Pathway analysis for RNA-Seq data using a score-based approach. " Biometrics DOI: 10.1111/biom.12372

Corvol, H., Blackman, S. M., Boelle, P., Gallins, P.J., Pace, R.G., Stonebraker, J.R., Ac- curso, F.J., Clement, A., Collaco, J.M., Dang, H., Dang, A.T., Franca, A., Gong, J., Guillot, L., Keenan, K., Li, W., Lin, F., Patrone, M.V., Raraigh, K.S., Sun, L., Zhou, Y.H., ONeal, W.K., Sontag, M.K., Levy, H., Durie, P.R., Rommens, J.M., Drumm, M.L., Wright, F.A., Strug, L.J., Cutting, G.R., Knowles, M.R. (2015). "Genome-wide association meta-analysis identifies five modifier loi of lung disease severity in cystic fibrosis." Nature Communications DOI: 10.1038/NCOMMS9382

Zhou, Y.H., Wright, F.A. (2015) “The projack: a resampling approach to correct for ranking bias in high throughput studies.” Biostatistics doi: 10.1093/biostatistics/kxv022

Zhou, Y.H., Wright, F.A. (2015) “Hypothesis testing at the extremes: fast and robust association for high-throughput data.” Biostatistics doi: 10.1093/biostatistics/kxv007

Zhou, Y.H., Marron, J.S. (2015) “High dimension low sample size asymptotics of robust PCA.” Electronic Journal of Statistics 9, 204-218

GTEx Consortium (2015) “The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans.” Sciences 348: 648-660

Rager, J.E., Tilley, S.K., Tulenko, S.E., Smeester, L., Ray, P.D., Yosin, A., Currier, J.M., Ishida, M.C., Gonzalez-Horta, M.D., Sanchez-Ramirez, B., Ballinas-Casarrubias, L., Gutierrez-Torres, D.S., Drobna, Z., Del, L.M., Garcia-Vargas, G.G., Kim, W.Y., Zhou, Y.H., Wright, F.A., Styblo, M., Fry, R.C.(2015). "Identification of novel gene targest and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer." Chemical Research in Toxicology DOI:10.1021/tx500393y

Demerath, E.W., Guan, W., Grove, M., Aslibekyan, S., Mendelson, M., Zhou, Y.H., Hed- man, A.K., Sandling, J.K., Li, L. , Irvin, M.R., Zhi, D., Deloukas, P., Liang, L., Liu, C., Bressler, J., Spector, T.D., North, K., Li, Y., Absher, D.M., Levy, D., Arnett, D.K., For- nage, M., Pankow, J.S., Boerwinkle, E. (2015) “Epigenome-wide association study (EWAS) of BMI, BMI change, and waist circumference in African American adults identi_es multiple replicated loci.” Human Molecular Genetics 2015 May 1. pii: ddv161

O’Neal, W.K., Gallins, P., Wolf, W.E., Jones, L.C., Guo, X., Zhou, Y.H., Madar, V., Huang, J. Liang, L., Moffatt, M.F., Cutting, G.R., Drumm, M.L., Rommens, J.M., Strug, L.J., Sun, W., Stonebraker, J.R., Wright, F.A., Knowles, M.R. (2015) “Gene Expression in Transformed Lymphocytes Reveals Variation in Endomembrane and HLA Pathways Modifying Cystic Fibrosis Pulmonary Phenotypes.” The American Journal of Human Genetics 96(2), 318-328

Esther, C.R., Zhou, Y.H., Wright, F.A., Boucher, R.C. (2015) “Metabolomic Evaluation Of Cystic Fibrosis Airways Disease.” Am J Respir Crit Care Med 187 A1165

Abdo, N., Xia, M., Brown, C.C., Kosyk, O., Huang, R., Sakamuru, S., Zhou, Y.H., Jack, J.R., Gallins, P., Xia, K., Li, Y., Chiu, W.A., Motsinger-Reif A.A., Austin, C.P., Tice, R.R., Rusyn, I., Wright, F.A. (2015) “Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.” Environmental Health Perspectives 123(5):458-66

Wright, F.A., Sullivan, P.F., Brooks, A.I., Zou, F., Su, W., Xia, K., Madar, V., Jansen, R., Chung, W., Zhou, Y.H., et al. (2014) “Heritability and genomics of gene expression in peripheral blood.” Nature Genetics 46 (5) 430-437

Chiu, W.A., Campbell, J.L., Clewell, H.J., Zhou, Y.H., Wright, F.A. Guyton, K.Z., Rusyn, I. (2014) “Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.” Environmental Health Perspectives 122 (5) 456

Zhou, Y.H., Barry, W.B., Wright, F.A. (2013). "Permutation-based expression pathway analysis, without permutation." An earlier version won an ENAR Distinguished Student Paper Award. Biostatistics (2013), 14 (3) 573-585

Zhou, Y.H., Wright, F.A. (2013). "Simple and accurate trend tests using a permutation approximation." (ISCA BICOB-2013)

Zhou, Y.H., Mayhew, G., Sun, Z., Xu, X., Zou, F., Wright, F.A. (2013) “Space–time clustering and the permutation moments of quadratic forms.” Stat 2 (1) 292-302

Sanders, A.P., Smeester, L., Rojas, D., DeBussycher, T., Wu, M.C., Wright, F.A., Zhou, Y.H., Laine, J.E., Rager, J.E., Swamy, G.K., Koch, A.A., Miranda, M.L., Fry, R.C. (2013) “Cadmium exposure and the epigenome: Exposure-associated patterns of DNA methylation in leukocytes from mother-baby pairs.” Epigenetics 9 (2) 0-9

Sun, Z., Oey, L., Zhou, Y.H. (2013) “Skill-assessments of statistical and Ensemble Kalman Filter data assimulative analyses using surface and deep observations in Gulf of Mexico.” Frontiers of Earth Science 7 (3) 271-281

Xu, M., Xu, X., Zhou, Y.H. (2013). “Stochastic comparisons in a price-quantity setting firm with uncertainty demand and emergency procurement.” Journal of Systems Science and Systems Engineering, 22 (4), 401-420.

Li, Y., Chen, W., Liu, Y.E., Zhou, Y.H. (2012). “Single nucleotide polymorphism (SNP) detection and genotype calling from massively parallel sequencing (MPS) data.” Statistics in Biosciences, DOI 10/1007/s12561-012-9067-4.

Lock, E.F., Abdo, N., Huang, R., Xia, M., Kosyk, O., Oshea, S.H., Zhou, Y.H., Sedykh, A., Tropsha, A., Austin, C.P., Tice, R.R., Wright, F.A., Rusyn, I. (2012). "Quantitative high-throughput screening for chemical toxicity in a population based in vitro model." Toxicological Sciences 126 (2): 578-588.

Xia, K., Shabalin, A.A., Huang, S., Madar, V., Zhou, Y.H., Wang, W., Zou, F., Sun, W., Sullivan, P.F., Wright, F.A.(2012) "seeQTL a searchable database for human eQTLs." Bioinformatics 28(3), 451-452.

Zhou, Y.H., Xia, K., Wright, F.A. (2011). "A Powerful and Flexible Approach to the Analysis of RNA Sequence Count Data." Bioinformatics: 27 (19) 2672-2678.

Zhou, Y.H., Gowda, M.S. (2009). "On the finiteness of the cone spectrum of certain linear transformations on Euclidean Jordan algebras." Linear Algebra and its Applications: 431 (5-7) 772-782.